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Proteins/UNIPROT:Q9NYB5
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane. Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases. Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency. Transports T4 and E1S in a pH-insensitive manner. Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain..
Function from UniProtKB (Q9NYB5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 7 reference databases · Subject: SLCO1C1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
Transported by SLCO4A1 or SLCO1B1 or SLCO1C1 or SLC16A2 or SLCO3A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06055CC BY 4.0Reference data
14 names
Resolves to: SLCO1C1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06096CC BY 4.0Reference data
hydrogencarbonate+3,3',5-triiodo-L-thyroninehydrogencarbonate+3,3',5-triiodo-L-thyronine
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO1C1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06098CC BY 4.0Reference data
estrone 3-sulfate+hydrogencarbonateestrone 3-sulfate+hydrogencarbonate
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO2B1 or SLCO1C1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06129CC BY 4.0Reference data
MAM02839cMAM02839e
Transported by SLCO4A1 or SLCO1B1 or SLCO1C1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06257CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate)17beta-estradiol 3-O-(beta-D-glucuronate)
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO1C1
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07649CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate)+hydrogencarbonate17beta-estradiol 3-O-(beta-D-glucuronate)+hydrogencarbonate
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO1C1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07651CC BY 4.0Reference data
3,3',5-triiodo-L-thyronine3,3',5-triiodo-L-thyronine
Transported by SLC16A2 or SLC7A5 or SLCO4C1 or SLC16A10 or SLCO4A1 or SLCO1C1 or SLC7A8 or SLC17A4
Reaction pageReversibleBalanced
Rhea RHEA:71811CC BY 4.0Reference data
3,3',5'-triiodo-L-thyronine3,3',5'-triiodo-L-thyronine
Transported by SLC16A2 or SLCO1A2 or SLC7A5 or SLCO4A1 or SLCO1C1 or SLCO1B1
Reaction pageLeft to rightBalanced
Rhea RHEA:71815CC BY 4.0Reference data
Transported by SLCO2B1 or SLC16A2 or SLCO1A2 or SLC7A5 or SLCO4C1 or SLC16A10 or SLCO4A1 or SLCO1B3 or SLCO1C1 or SLCO3A1 or SLC17A4 or SLCO1B1
Reaction pageReversibleBalanced
Rhea RHEA:71819CC BY 4.0Reference data
estrone 3-sulfateestrone 3-sulfate
Transported by SLCO2B1 or SLCO1A2 or SLCO4C1 or SLC51A or SLC51B or SLCO4A1 or SLCO1B3 or SLCO1C1 or SLCO3A1 or SLC22A7 or SLCO1B1
Reaction pageLeft to rightBalanced
Rhea RHEA:71835CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)17beta-estradiol 17-O-(beta-D-glucuronate)
Transported by SLCO1B3-SLCO1B7 or SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1C1 or SLCO1B1
Reaction pageLeft to rightBalanced
Rhea RHEA:72691CC BY 4.0Reference data