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Proteins/UNIPROT:Q9UGN4

CD300A

Protein·UNIPROT:Q9UGN4

Open in the graph

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6..

Function from UniProtKB (Q9UGN4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

28 statements

28 statements · 4 reference databases · Subject: CD300A · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ANKMY1 covaries with CD300AProteinHetionet hetionet:covaries:11314-51281Inferred only
CD300A covaries with CACNA1SProteinHetionet hetionet:covaries:11314-779Inferred only
CD300A covaries with HSD17B7ProteinHetionet hetionet:covaries:11314-51478Inferred only
CD300A participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
CD300A participates in Dengue Virus Attachment and EntryPathwayReactome R-HSA-9918485Inferred only
CD300A participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
CD300A participates in DiseasePathwayReactome R-HSA-1643685Inferred only
CD300A participates in Ebola virus infection in hostPathwayWikiPathways WP4217Inferred only
CD300A participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CD300A participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only
CD300A participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
CD300A participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only

Show the remaining 16

CD300A participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
CD300A participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
CD300A regulates negative regulation of B cell proliferationBiological processgene ontology Q9UGN4|GO:0030889Inferred only
CD300A regulates negative regulation of B cell receptor signaling pathwayBiological processgene ontology Q9UGN4|GO:0050859Inferred only
CD300A regulates negative regulation of eosinophil activationBiological processgene ontology Q9UGN4|GO:1902567Inferred only
CD300A regulates negative regulation of eosinophil migrationBiological processgene ontology Q9UGN4|GO:2000417Inferred only
CD300A regulates negative regulation of fibroblast proliferationBiological processgene ontology Q9UGN4|GO:0048147Inferred only
CD300A regulates negative regulation of MAP kinase activityBiological processgene ontology Q9UGN4|GO:0043407Inferred only
CD300A regulates negative regulation of mast cell activation involved in immune responseBiological processgene ontology Q9UGN4|GO:0033007Inferred only
CD300A regulates negative regulation of mast cell degranulationBiological processgene ontology Q9UGN4|GO:0043305Inferred only
CD300A regulates negative regulation of MyD88-dependent toll-like receptor signaling pathwayBiological processgene ontology Q9UGN4|GO:0034125Inferred only
CD300A regulates negative regulation of neutrophil activationBiological processgene ontology Q9UGN4|GO:1902564Inferred only
CD300A regulates negative regulation of NK T cell activationBiological processgene ontology Q9UGN4|GO:0051134Inferred only
CD300A regulates negative regulation of phagocytosis, engulfmentBiological processgene ontology Q9UGN4|GO:0060101Inferred only
CD300A regulates regulation of innate immune responseBiological processgene ontology Q9UGN4|GO:0045088Inferred only
CD300A regulates regulation of T cell receptor signaling pathwayBiological processgene ontology Q9UGN4|GO:0050856Inferred only

Other names

13 names

Resolves to: CD300A

Also called: CD antigen CD300aCD300 antigen-like family member ACLM-8CMRF-35-H9CMRF35-HCMRF35-H9CMRF35HIGSF12Immunoglobulin superfamily member 12Inhibitory receptor protein 60IRC1/IRC2IRp60NK inhibitory receptor

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