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Proteins/UNIPROT:P48058
Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate..
Function from UniProtKB (P48058), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 3 · transported by
3 compounds
3 compounds.
0 reported routes3 assembled routes
1 row
39 statements
39 statements · 6 reference databases · Subject: GRIA4 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, WikiPathways
3 reactions
6 names
Resolves to: GRIA4
Transported by TMEM150C or TRPA1 or VDAC1 or GRIA1 or HTR3A or GRIA4 or CLDN10 or NIPAL4 or TMEM63B or NIPAL1 or NIPA1 or PKD1L3 and 17 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29827CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data