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Proteins/UNIPROT:Q9UBD6
Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+). May act as a CO2 channel providing for renal acid secretion..
Function from UniProtKB (Q9UBD6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 7 reference databases · Subject: RHCG · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
5 reactions
Transported by RHAG or RHBG or RHCG
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR05022CC BY 4.0Reference data
proton+methylamineproton+methylamine
Reaction pageReversibleBalancedcytosol, extracellular space
9 names
Resolves to: RHCG
Transported by KCNK1 or AQP9 or CNGA1 or CHRNA7 or CLDN15 or CLDN10 or RHAG or AQP6 or CNGB1 or CNGA2 or CNGA3 or CNGA4 and 4 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:28747CC BY 4.0Reference data
Transported by AQP8 or CLDN15 or CLDN2 or CLDN10 or RHAG or RHBG or RHCG
Reaction pageLeft to rightBalanced
Rhea RHEA:74391CC BY 4.0Reference data
Transported by AQP1 or RHAG or AQP6 or RHBG or RHCG
Reaction pageLeft to rightBalanced
Rhea RHEA:74891CC BY 4.0Reference data