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Proteins/UNIPROT:P29973
Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels..
Function from UniProtKB (P29973), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
16 statements
16 statements · 4 reference databases · Subject: CNGA1 · Sources: Hetionet, Reactome, Rhea, WikiPathways
7 reactions
8 names
Resolves to: CNGA1
Transported by ANO9 or HTR3E or KCNU1 or KCNJ18 or TMEM150C or KCNK1 or KCNK3 or GRIN2D or KCNN4 or KCNQ3 or KCNQ2 or HCN1 and 136 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data
Transported by KCNK1 or KCNQ3 or KCNQ2 or KCNK2 or CNGA1 or CLDN15 or CLDN2 or KCNK10 or CLDN10 or CNGB1 or CNGA2 or CNGA3 and 8 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:78547CC BY 4.0Reference data
Transported by KCNK1 or CNGA1 or GRIA1 or TRPC1 or CLDN15 or CLDN2 or ASIC1 or CLDN10 or CNGB1 or CNGA2 or CNGA3 or ASIC2 and 7 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:78551CC BY 4.0Reference data