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Proteins/UNIPROT:P78348
Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory. Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents. Displays high selectivity for sodium ions but can also permit the permeation of other cations. Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity)..
[Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium..
[Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster. Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present. Also potentially permeable to lithium and potassium..
[Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro..
Function from UniProtKB (P78348), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
15 statements
15 statements · 4 reference databases · Subject: ASIC1 · Sources: gene ontology, Hetionet, Reactome, Rhea
4 reactions
4 names
Resolves to: ASIC1
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data