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Proteins/UNIPROT:O43315
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium (By similarity)..
Function from UniProtKB (O43315), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 7 reference databases · Subject: AQP9 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
16 reactions
Transported by AQP9 or SLC14A2 or SLC14A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04949CC BY 4.0Reference data
Transported by AQP9
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04951CC BY 4.0Reference data
MAM01983e+
4 names
Resolves to: AQP9
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09890CC BY 4.0Reference data
Transported by KCNK1 or AQP9 or CNGA1 or CHRNA7 or CLDN15 or CLDN10 or RHAG or AQP6 or CNGB1 or CNGA2 or CNGA3 or CNGA4 and 4 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:28747CC BY 4.0Reference data
Transported by AQP7B or AQP12B or AQP7 or AQP9 or AQP8 or AQP1 or MIP or AQP2 or AQP5 or AQP4 or CLDN15 or CLDN2 and 5 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29667CC BY 4.0Reference data
Transported by AQP7B or AQP7 or AQP9 or AQP1 or AQP2 or AQP11 or AQP3 or AQP10
Reaction pageDirection not assertedBalanced
Rhea RHEA:29675CC BY 4.0Reference data
Transported by AQP7 or AQP9 or SLC14A1 or SLC14A2 or AQP3 or AQP10
Reaction pageDirection not assertedBalanced
Rhea RHEA:32799CC BY 4.0Reference data
Transported by AQP9
Reaction pageDirection not assertedBalanced
Rhea RHEA:34891CC BY 4.0Reference data
Transported by AQP9
Reaction pageDirection not assertedBalanced
Rhea RHEA:34987CC BY 4.0Reference data
Transported by AQP9 or SLC29A2 or SLC29A1 or SLC29A3
Reaction pageReversibleBalanced
Rhea RHEA:69404CC BY 4.0Reference data
Transported by AQP9 or SLC29A2 or SLC43A3 or SLC29A1
Reaction pageReversibleBalanced
Rhea RHEA:71523CC BY 4.0Reference data
hydrogen peroxidehydrogen peroxide
Transported by AQP9 or AQP8 or AQP1 or AQP11 or AQP3
Reaction pageDirection not assertedBalanced
Rhea RHEA:74375CC BY 4.0Reference data