hereditary spastic paraplegia

Findings

No curated finding names hereditary spastic paraplegia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

Definition

What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, hp/releases/2026-09-01.

Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.

Where it sits

A kind of

• hereditary neuromuscular disease
• inherited neurodegenerative disorder
• paraplegia

Narrower terms (45)

• ADAR-related hereditary spastic paraplegia
• Charcot-Marie-Tooth disease type 5
• complex hereditary spastic paraplegia
• early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome
• hereditary spastic paraplegia 10
• hereditary spastic paraplegia 13
• hereditary spastic paraplegia 14
• hereditary spastic paraplegia 16
• hereditary spastic paraplegia 2
• hereditary spastic paraplegia 30
• hereditary spastic paraplegia 31
• hereditary spastic paraplegia 33
• hereditary spastic paraplegia 35
• hereditary spastic paraplegia 3A
• hereditary spastic paraplegia 4
• hereditary spastic paraplegia 47
• hereditary spastic paraplegia 48

Resolves to: hereditary spastic paraplegia

Also called

familial spastic paraplegiahereditary spastic paraparesisHSPSPGStrümpell-Lorrain disease