Pathway
Post-translational modification: synthesis of GPI-anchored proteins
Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.
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As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus.
REACT:R-HSA-163125Reactome
What the reference databases state
Statements
84 statements
84 statements · 1 reference database · Subject: Post-translational modification: synthesis of GPI-anchored proteins · Sources: Reactome
- ALPG participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- ALPI participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- ALPL participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- ART3 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- ART4 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- BST1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- CD109 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- CEACAM5 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- CEACAM7 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- CNTN3 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- CNTN4 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- CNTN5 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
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- CPM participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- DPM1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- DPM2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- DPM3 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- FCGR3B participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- FOLR2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- GP2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- GPAA1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- GPIHBP1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- GPLD1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- IZUMO1R participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LSAMP participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LY6D participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LY6E participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LY6H participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LY6K participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LYPD1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LYPD2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LYPD3 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LYPD4 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- LYPD5 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- MDGA1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- MDGA2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- MELTF participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- MSLN participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- NEGR1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- NRN1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- NRN1L participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- NTM participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- NTNG1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- NTNG2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- OPCML participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- OTOA participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PGAP1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGA participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGB participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGC participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGF participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGG participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGH participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGK participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGL participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGM participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGN participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGO participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGP participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGS participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGT participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGU participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGV participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGW participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGX participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGY participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PIGZ participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PLAUR participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PLET1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PRND participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PRSS21 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PRSS41 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- PSCA participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- RAET1G participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- RECK participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- RTN4RL1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- RTN4RL2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- SPRN participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- TECTA participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- TEX101 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- THY1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- ULBP2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- VNN1 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- VNN2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only
- XPNPEP2 participates in Post-translational modification: synthesis of GPI-anchored proteinsProteinReactome R-HSA-163125Inferred only