Proteins/UNIPROT:O75015

FCGR3B

ProteinUNIPROT:O75015

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Function from UniProtKB (O75015), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

systemic lupus erythematosus has a germline basis in FCGR3BDiseaseGenCC HGNC:3620|MONDO:0007915Inferred only

Statements

7 statements

7 statements · 2 reference databases · Subject: FCGR3B · Sources: Hetionet, Reactome

Order

APCS interacts with FCGR3BProteinHetionet hetionet:interacts:2215-325Inferred only
FCGR3B participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FCGR3B participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
FCGR3B participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
FCGR3B participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
FCGR3B participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
FCGR3B participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Other names

13 names

Resolves to: FCGR3B

Also called: CD antigen CD16bCD16-ICD16BFc-gamma RIIIFc-gamma RIII-betaFc-gamma RIIIbFCG3FCGR3FcR-10FcRIIIFcRIIIbIGFR3IgG Fc receptor III-1

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