Proteins/UNIPROT:O95980

RECK

ProteinUNIPROT:O95980

Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity. Also inhibits metalloproteinase activity of MMP2, MMP14 (MT1-MMP) and ADAM10..

Function from UniProtKB (O95980), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

23 statements

23 statements · 3 reference databases · Subject: RECK · Sources: gene ontology, Hetionet, Reactome

Order

CCDC160 covaries with RECKProteinHetionet hetionet:covaries:347475-8434Inferred only
RECK covaries with SIN3BProteinHetionet hetionet:covaries:23309-8434Inferred only
RECK covaries with ZNF875ProteinHetionet hetionet:covaries:284459-8434Inferred only
ERBB2 interacts with RECKProteinHetionet hetionet:interacts:2064-8434Inferred only
MMP9 interacts with RECKProteinHetionet hetionet:interacts:4318-8434Inferred only
RECK participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
RECK participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
RECK participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
RECK regulates negative regulation of cell migrationBiological processgene ontology O95980|GO:0030336Inferred only
RECK regulates negative regulation of extracellular matrix disassemblyBiological processgene ontology O95980|GO:0010716Inferred only
RECK regulates positive regulation of amyloid precursor protein biosynthetic processBiological processgene ontology O95980|GO:0042986Inferred only
RECK regulates positive regulation of amyloid-beta formationBiological processgene ontology O95980|GO:1902004Inferred only

Show the remaining 11

RECK regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology O95980|GO:0090263Inferred only
RECK regulates regulation of angiogenesisBiological processgene ontology O95980|GO:0045765Inferred only
RECK regulates regulation of canonical Wnt signaling pathwayBiological processgene ontology O95980|GO:0060828Inferred only
RECK regulates regulation of establishment of blood-brain barrierBiological processgene ontology O95980|GO:0090210Inferred only
RECK regulates regulation of extracellular matrix organizationBiological processgene ontology O95980|GO:1903053Inferred only
ACAT2 increases the expression of RECKProteinHetionet hetionet:regulates:39-8434Inferred only
BRD4 increases the expression of RECKProteinHetionet hetionet:regulates:23476-8434Inferred only
CD320 increases the expression of RECKProteinHetionet hetionet:regulates:51293-8434Inferred only
EGFR increases the expression of RECKProteinHetionet hetionet:regulates:1956-8434Inferred only
MELK decreases the expression of RECKProteinHetionet hetionet:regulates:9833-8434Inferred only
UBE2L6 decreases the expression of RECKProteinHetionet hetionet:regulates:9246-8434Inferred only

Other names

3 names

Resolves to: RECK

Also called: hRECKST15Suppressor of tumorigenicity 15 protein

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