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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O60762

DPM1

Protein·UNIPROT:O60762

Open in the graph

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex..

Function from UniProtKB (O60762), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

congenital disorder of glycosylation type 1E has a germline basis in DPM1DiseaseGenCC HGNC:3005|MONDO:0012123Inferred only

Statements

36 statements

36 statements · 4 reference databases · Subject: DPM1 · Sources: Hetionet, Reactome, UniProt, WikiPathways

Search this listOrder

DPM1 interacts with DPM2ProteinHetionet hetionet:interacts:8813-8818Inferred only
DPM1 interacts with DPM3ProteinHetionet hetionet:interacts:54344-8813Inferred only
MTNR1A interacts with DPM1ProteinHetionet hetionet:interacts:4543-8813Inferred only
MYC interacts with DPM1ProteinHetionet hetionet:interacts:4609-8813Inferred only
DPM1 interacts with STUB1ProteinHetionet hetionet:interacts:10273-8813Inferred only
UBC interacts with DPM1ProteinHetionet hetionet:interacts:7316-8813Inferred only
ZBTB16 interacts with DPM1ProteinHetionet hetionet:interacts:7704-8813Inferred only
DPM1 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
DPM1 participates in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinPathwayReactome R-HSA-446193Inferred only
DPM1 participates in Defective DPM1 causes DPM1-CDGPathwayReactome R-HSA-4717374Inferred only
DPM1 participates in Defective DPM2 causes DPM2-CDGPathwayReactome R-HSA-4719377Inferred only
DPM1 participates in Defective DPM3 causes DPM3-CDGPathwayReactome R-HSA-4719360Inferred only

Show the remaining 24

DPM1 participates in Dengue Virus Genome Translation and ReplicationPathwayReactome R-HSA-9918487Inferred only
DPM1 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
DPM1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
DPM1 participates in Diseases associated with glycosylation precursor biosynthesisPathwayReactome R-HSA-5609975Inferred only
DPM1 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
DPM1 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
DPM1 participates in Glycosylation and related congenital defectsPathwayWikiPathways WP4521Inferred only
DPM1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
DPM1 participates in Maturation of DENV proteinsPathwayReactome R-HSA-9918432Inferred only
DPM1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
DPM1 participates in N glycan biosynthesisPathwayWikiPathways WP5153Inferred only
DPM1 participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
DPM1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DPM1 participates in Synthesis of dolichyl-phosphate mannosePathwayReactome R-HSA-162699Inferred only
DPM1 participates in Synthesis of substrates in N-glycan biosythesisPathwayReactome R-HSA-446219Inferred only
DPM1 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
DPM1 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
ANKRD49 decreases the expression of DPM1ProteinHetionet hetionet:regulates:54851-8813Inferred only
ASL decreases the expression of DPM1ProteinHetionet hetionet:regulates:435-8813Inferred only
FBXL12 increases the expression of DPM1ProteinHetionet hetionet:regulates:54850-8813Inferred only
RHOA decreases the expression of DPM1ProteinHetionet hetionet:regulates:387-8813Inferred only
DPM1 requires the cofactor Ca(2+)CompoundUniProt O60762Inferred only
DPM1 requires the cofactor magnesium(2+)CompoundUniProt O60762Inferred only
DPM1 requires the cofactor Mn(2+)CompoundUniProt O60762Inferred only

Reactions

3 reactions

MAM01733c+MAM01951cMAM01734c+GDP
Catalysed by DPM1 & DPM2 & DPM3 or ALG12
Reaction pageLeft to rightBalancedEC 2.4.1.83cytosol
Human-GEM MAR07271CC BY 4.0Reference data
MAM01734r+MAM01896rMAM01733r+MAM01897r+proton
Catalysed by DPM1 & DPM2 & DPM3

Other names

5 names

Resolves to: DPM1

Also called: Dolichol-phosphate mannose synthase subunit 1Dolichyl-phosphate beta-D-mannosyltransferase subunit 1DPM synthase subunit 1Mannose-P-dolichol synthase subunit 1MPD synthase subunit 1

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or

Reaction pageLeft to rightBalancedEC 2.4.1.259endoplasmic reticulum

Human-GEM MAR07275CC BY 4.0Reference data

a di-trans,poly-cis-dolichyl phosphate+CHEBI:57527a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate+GDP

Catalysed by DPM1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:21184CC BY 4.0Reference data