Proteins/UNIPROT:A6ND01

IZUMO1R

ProteinUNIPROT:A6ND01

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate..

Function from UniProtKB (A6ND01), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: IZUMO1R · Sources: Hetionet, Reactome, WikiPathways

Order

IZUMO1R covaries with EWSR1ProteinHetionet hetionet:covaries:2130-390243Inferred only
IZUMO1R covaries with FAT3ProteinHetionet hetionet:covaries:120114-390243Inferred only
IZUMO1R covaries with RNF2ProteinHetionet hetionet:covaries:390243-6045Inferred only
IZUMO1R covaries with SNPHProteinHetionet hetionet:covaries:390243-9751Inferred only
IZUMO1R participates in Folate metabolismPathwayWikiPathways WP176Inferred only
IZUMO1R participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
IZUMO1R participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
IZUMO1R participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Other names

6 names

Resolves to: IZUMO1R

Also called: Folate receptor 4Folate receptor deltaFOLR4FR-deltaIZUMO1 receptor protein JUNOJUNO

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