Proteins/UNIPROT:Q969N2

PIGT

ProteinUNIPROT:Q969N2

Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. May play a crucial role in GPI-T complex assembly in the luminal layer. Binds GPI-anchor..

Function from UniProtKB (Q969N2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

multiple congenital anomalies-hypotonia-seizures syndrome 3 has a germline basis in PIGTDiseaseGenCC HGNC:14938|MONDO:0014165Inferred only

Statements

22 statements

22 statements · 3 reference databases · Subject: PIGT · Sources: Hetionet, Reactome, WikiPathways

Order

FBXO6 interacts with PIGTProteinHetionet hetionet:interacts:26270-51604Inferred only
GPAA1 interacts with PIGTProteinHetionet hetionet:interacts:51604-8733Inferred only
PIGK interacts with PIGTProteinHetionet hetionet:interacts:10026-51604Inferred only
SUMO2 interacts with PIGTProteinHetionet hetionet:interacts:51604-6613Inferred only
UBC interacts with PIGTProteinHetionet hetionet:interacts:51604-7316Inferred only
PIGT interacts with UPF3AProteinHetionet hetionet:interacts:51604-65110Inferred only
PIGT participates in Attachment of GPI anchor to uPARPathwayReactome R-HSA-162791Inferred only
PIGT participates in Glycosylphosphatidyl inositol anchor pathwayPathwayWikiPathways WP5505Inferred only
PIGT participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PIGT participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
PIGT participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DCPS decreases the expression of PIGTProteinHetionet hetionet:regulates:28960-51604Inferred only

Show the remaining 10

DLD decreases the expression of PIGTProteinHetionet hetionet:regulates:1738-51604Inferred only
FBP1 increases the expression of PIGTProteinHetionet hetionet:regulates:2203-51604Inferred only
FHL2 decreases the expression of PIGTProteinHetionet hetionet:regulates:2274-51604Inferred only
HORMAD2 decreases the expression of PIGTProteinHetionet hetionet:regulates:150280-51604Inferred only
HSF1 increases the expression of PIGTProteinHetionet hetionet:regulates:3297-51604Inferred only
KIF2C increases the expression of PIGTProteinHetionet hetionet:regulates:11004-51604Inferred only
NDUFA1 decreases the expression of PIGTProteinHetionet hetionet:regulates:4694-51604Inferred only
NUP133 decreases the expression of PIGTProteinHetionet hetionet:regulates:55746-51604Inferred only
PAFAH1B3 increases the expression of PIGTProteinHetionet hetionet:regulates:5050-51604Inferred only
STK25 increases the expression of PIGTProteinHetionet hetionet:regulates:10494-51604Inferred only

Reactions

4 reactions

MAM01779r+MAM02001rMAM01780r+MAM02022r
Catalysed by GPAA1 & PIGK & PIGT & PIGS & PIGU
Reaction pageLeft to rightBalance undeterminableEC 2.6.1.-endoplasmic reticulum
Human-GEM MAR08402CC BY 4.0Reference data
MAM02001r+MAM02020rMAM02021r+MAM02022r
Catalysed by GPAA1 & PIGK & PIGT & PIGS

Other names

2 names

Resolves to: PIGT

Also called: GPI-anchor transamidase component PIGTPhosphatidylinositol-glycan biosynthesis class T protein

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