Loading the page.
Proteins/UNIPROT:Q9H3S5
Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) intermediate to generate 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis..
Function from UniProtKB (Q9H3S5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
11 statements
11 statements · 4 reference databases · Subject: PIGM · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
3 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
4 names
Resolves to: PIGM
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
MAM01734r+MAM01964rMAM01733r+proton+MAM02483r
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR08383CC BY 4.0Reference data
CHEBI:143817+a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphatea 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by PIGM
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60500CC BY 4.0Reference data