L-cysteinylglycine

Three steps

• (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 8 morecytosol, extracellular space

• 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 28 morecytosol, extracellular spaceOne of 4 routes

• 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 28 morecytosol, extracellular spaceOne of 2 routes

• 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine

  Catalysed by ANPEP, LAP3, NPEPPS, GLYATL2 and 2 morecytosol

• N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine

  Catalysed by ANPEP, LAP3, NPEPPS, GLYATL2 and 3 morecytosol

• (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• a quinoneReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

  Catalysed by CHAC2, CHAC1, SQOR, CYC1 and 1 moreouter side of the membraneOne of 6 routes

• prostaglandin H3Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular space

• prostaglandin J2Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. prostaglandin J2 hydrolysis

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. 15-keto-prostaglandin F2alpha reduction

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 4 routes

• dopamine 3-O-sulfateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 8 morecytosol, extracellular space

• dopamine 4-O-sulfateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Dopamine 4-O-Sulfotransferase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 6 morecytosol, extracellular spaceOne of 2 routes

• epsilon-(gamma-L-glutamyl)-L-lysineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

  Catalysed by CHAC2, CHAC1, GGACT

• 13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• 9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 1 morecytosol, extracellular space

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 1 morecytosol, extracellular spaceOne of 2 routes

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A9 and 2 morecytosol, extracellular space

• 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 28 morecytosol, extracellular spaceOne of 2 routes

• 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 28 morecytosol, extracellular spaceOne of 2 routes

• 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• (13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 5 morecytosol

• acetoacetateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. transport of acetoacetate and pyruvate (cytosol to mitochondria)

  Catalysed by ANPEP, LAP3, NPEPPS, CTHcytosol, mitochondrial matrixOne of 4 routes

• 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 28 morecytosol, extracellular space

• (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by CHAC2, CHAC1, PTGES, MGST3 and 5 more

• 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• 2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• 3-sulfinopyruvateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-Cysteine:oxygen oxidoreductase
  3. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase

  Catalysed by ANPEP, LAP3, NPEPPS, CDO1 and 1 morecytosolOne of 2 routes

• an organic moleculeReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CHAC2, CHAC1, CP, PRDX6 and 25 more

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosolOne of 3 routes

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosolOne of 3 routes

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosolOne of 3 routes

• N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosolOne of 3 routes

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosolOne of 3 routes

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by ANPEP, LAP3, NPEPPS, AADAT and 1 morecytosolOne of 2 routes

• D-histidineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6 and 1 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6 and 1 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-homocarnosineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and histidine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6 and 1 morecytosol, extracellular space

• an S-substituted L-cysteinylglycineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
  3. an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate

  Catalysed by CHAC2, CHAC1, GSTT4, GSTA4 and 26 more

• (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by CHAC2, CHAC1, GPX1, GPX4 and 1 more

• 2,3-didehydrophenylalanineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by ANPEP, LAP3, NPEPPS, DPEP1cytosol

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 2 morecytosol, extracellular spaceOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. L-cysteinylglycine dipeptidase
  2. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
  3. N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, GARTcytosol