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1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

257 compounds within 3 steps: 4 in 1, 65 in 2, 188 in 3

Does it reach a compound?

Two steps

1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15One of 5 routes
2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-octadecanoyl-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15One of 9 routes
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15One of 2 routes
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15One of 3 routes
2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15One of 3 routes
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15
2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
Catalysed by PAFAH2, PLA2G15
1-O-hexadecyl-sn-glycero-3-phosphateReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
2. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 6 more
1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by PAFAH2, PLA2G15
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by PAFAH2, PLA2G15One of 8 routes
N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
1. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
2. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)
Catalysed by PAFAH2, CERK

Three steps

(S)-3-hydroxybutanoateReach from here →
Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosol
CHEBI:1146900Reach from here →

Page 2 of 6

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 7 morecytosolOne of 2 routes

AReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PAFAH2, PLA2G15, PTGS2One of 3 routes

1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PAFAH2, PLA2G15, CYP2W1

1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PAFAH2, PLA2G15, CYP2W1

1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PAFAH2, PLA2G15, CYP2W1

1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by PAFAH2, PLA2G15, CYP2W1

prostaglandin E3Reach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin E3, Lactate Antiport

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosolOne of 2 routes

prostaglandin A2Reach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin A2, Lactate Antiport

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosolOne of 2 routes

prostaglandin J2Reach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of Prostaglandin J2, Lactate Antiport

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and L-lactate (cytosol to extracellular)
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosolOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 7 moreextracellular space, cytosolOne of 3 routes

2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PAFAH2, PLA2G15, PTGS2

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PAFAH2, PLA2G15, PTGS2

2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O

Catalysed by PAFAH2, PLA2G15, PTGS2

2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine

Catalysed by PAFAH2, PLA2G15, PTGS2

2-(prostaglandin G2)-sn-glycero-3-phosphocholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine

Catalysed by PAFAH2, PLA2G15, PTGS2

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and retinoate (cytosol to extracellular)
glucuronosyltransferase (retinoate)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosol, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and retinoate (cytosol to extracellular)
unspecific monooxygenase (retinoate)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 31 moreextracellular space, cytosolOne of 2 routes

acetaldehydeReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
cytochrome P450 (17alpha-hydroxypregnenolone)
cytochrome P450 (17alpha-hydroxypregnenolone)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 4 moreendoplasmic reticulum, cytosolOne of 3 routes

CHEBI:15345Reach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and acetoacetate (cytosol to extracellular)
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosolOne of 3 routes

acetoneReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and acetoacetate (cytosol to extracellular)
Acetoacetate carboxy-lyase (acetone-forming)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 8 moreextracellular space, cytosol, mitochondrial matrix

acetylcholineReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
Acetyl-CoA:choline O-acetyltransferase

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 7 morecytosolOne of 3 routes

propionyl-CoAReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and propanoate (cytosol to extracellular)
Propanoate:CoA ligase (AMP-forming)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 10 moreextracellular space, cytosolOne of 3 routes

(S)-malateReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
(S)-malate + NAD(+) = pyruvate + CO2 + NADH

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosolOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and formate (cytosol to extracellular)
Formate:tetrahydrofolate ligase (ADP-forming)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 7 moreextracellular space, cytosolOne of 2 routes

betaine aldehydeReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
choline dehydrogenase (choline)

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 7 morecytosolOne of 3 routes

alpha-D-glucosamine 6-phosphateReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 5 morecytosol

a sterolReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

Catalysed by PAFAH2, PLA2G15, LCAT

CHEBI:15978Reach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
sn-Glycero-3-phosphocholine glycerophosphohydrolase

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 5 morecytosol

2-methyl-3-oxopropanoic acidReach from here →

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)
transport of acetate and pyruvate (cytosol to extracellular)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by PLA2G10, PLA2G6, PAFAH1B2, PLA2G7 and 9 moreextracellular space, cytosol, mitochondrial matrix