an N-acylsphinganine

1. delta 4-desaturase, sphingolipid (dihydroceramide pool)
2. acyl-CoA:sphingosine N-acyltransferase

Catalysed by DEGS1, DEGS2, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

Catalysed by SGMS2, SAMD8, DGKI, DGKA and 9 more

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)

Catalysed by ACER2, ACER1, ACER3, RPE65

1. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
2. Phytoceramide amidohydrolase

Catalysed by DEGS1, DEGS2, ASAH1, ACER2 and 3 morecytosolOne of 2 routes

1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)

Catalysed by SGMS2, SAMD8, SELENOI, CEPT1

1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
2. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

Catalysed by SGMS2, SAMD8, DGAT1, MOGAT2 and 4 more

1. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
2. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS2, SAMD8, SGMS1

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS3 and 2 more

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. 2-hydroxydocosanoyl-CoA + sphinganine = N-(2-hydroxydocosanoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS3 and 1 more

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS1 and 2 more

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS1 and 5 more

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. 2-hydroxyoctadecanoyl-CoA + sphinganine = N-(2-hydroxyoctadecanoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS1 and 1 more

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS6 and 2 moreOne of 2 routes

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. 2-hydroxyhexadecanoyl-CoA + sphinganine = N-(2-hydroxyhexadecanoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS5

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS6 and 1 more

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. octacosanoyl-CoA + sphinganine = N-(octacosanoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS3

1. delta 4-desaturase, sphingolipid (dihydroceramide pool)
2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

Catalysed by DEGS1, DEGS2, SGMS1, SGMS2 and 1 morecytosol

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS5 and 1 more

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS2

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. tetracosenoyl-CoA + sphinganine = an N-tetracosenoylsphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS2

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. hexacosenoyl-CoA + sphinganine = N-hexacosenoylsphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS2

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. 2-hydroxytetracosenoyl-CoA + sphinganine = N-(2-hydroxytetracosenoyl)-sphinganine + CoA + H(+)

Catalysed by ACER2, ACER1, ACER3, CERS2

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

Catalysed by ACER2, ACER1, ACER3, ABHD11

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate

Catalysed by ACER2, ACER1, ACER3, ACSL3

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
2. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

Catalysed by DEGS1, DEGS2, SGMS1, SGMS2cytosol

1. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
2. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

Catalysed by DEGS1, DEGS2, SGMS2, SAMD8cytosol

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol, extracellular spaceOne of 12 routes

1. delta 4-desaturase, sphingolipid (dihydroceramide pool)
2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

Catalysed by DEGS1, DEGS2, SGMS2cytosol

1. delta 4-desaturase, sphingolipid (dihydroceramide pool)
2. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine

Catalysed by DEGS1, DEGS2, SGMS1, SGMS2cytosol

1. an N-acylsphinganine + H2O = sphinganine + a fatty acid
2. N-(dodecanoyl)-sphinganine + H2O = dodecanoate + sphinganine

Catalysed by ACER2, ACER1, ACER3, ASAH1

1. N-acylsphingosine amidohydrolase
2. sphingosine N-acyltransferase (sphinganine)
3. Carnitine O-Palmitoyltransferase

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 10 morecytosolOne of 260 routes

1. N-acylsphingosine amidohydrolase
2. (10Z)-heptadecenoic acid formation
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

Catalysed by and 3 more