desmosterol

Three steps

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT1

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. dodecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT3, LPCAT1

• 1-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine

  Catalysed by DHCR24, LCAT, PLA2G4C

• nonadecanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 2 moreendoplasmic reticulum, cytosolOne of 3 routes

• 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT2, LPCAT1One of 2 routes

• 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT1

• 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. hexanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT1

• 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT1

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT1

• 1-hexadecanoyl-sn-glycerolReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by DHCR24, LCAT, SMPD2, ENPP6 and 2 more

• 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by DHCR24, LCAT, TAFAZZIN

• beta-D-glucosyl-N-dodecanoylsphing-4-enineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by DHCR24, GBA1, GBA2One of 2 routes

• beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by DHCR24, GBA1, GBA2One of 2 routes

• dodecanedioyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by DHCR24, SOAT2, SOAT1endoplasmic reticulum, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 2 moreendoplasmic reticulum, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Production of Suberylcarnitine

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 2 moreendoplasmic reticulum, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by DHCR24, SOAT2, SOAT1endoplasmic reticulum, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 2 moreendoplasmic reticulum, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by DHCR24, SOAT2, SOAT1, CRAT and 1 moreendoplasmic reticulum, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by DHCR24, SOAT2, SOAT1, ACAA1 and 3 moreendoplasmic reticulum, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by DHCR24, SOAT2, SOAT1, CPT1A and 2 moreendoplasmic reticulum, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2endoplasmic reticulum, cytosolOne of 2 routes

• 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine

  Catalysed by DHCR24, LCAT, PLA2G4C

• undecanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, ACSM4 and 5 moreendoplasmic reticulum, cytosolOne of 3 routes

• hexadecanoateReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)

  Catalysed by DHCR24, LCAT, PLA2G6, LYPLA1 and 15 moreOne of 2 routes

• 7alpha-hydroxypregnenoloneReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. cytochrome P450 (cholesterol)
  3. pregnenolone,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)

  Catalysed by DHCR24, CYP11A1, CYP7B1endoplasmic reticulum, mitochondrial matrix, cytosolOne of 2 routes

• (24S)-24-hydroxycholesterol esterReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + (24S)-hydroxycholesterol = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by DHCR24, CYP46A1, LCATendoplasmic reticulum

• (24S)-hydroxycholesterol 3-linoleoateReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by DHCR24, CYP46A1, LCATendoplasmic reticulum

• 1,2-dihexadecanoyl-sn-glycerolReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by DHCR24, GBA1, GBA2, SGMS2

• 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DHCR24, LCAT, LPCAT1

• 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine

  Catalysed by DHCR24, GBA1, GBA2, SGMS1 and 1 more

• (5Z)-tetradecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 8 routes

• beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by DHCR24, GBA1, GBA2One of 2 routes

• beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enineReach from here →
  1. cholesterol + NADP(+) = desmosterol + NADPH + H(+)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

  Catalysed by DHCR24, GBA1, GBA2One of 2 routes

• (3E)-decenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by DHCR24, SOAT2, SOAT1, ACADM and 3 moreendoplasmic reticulum, mitochondrial matrix

• 24S,25-dihydroxycholesterolReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. (24S)-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 24S,25-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by DHCR24, CYP46A1endoplasmic reticulum

• (24S,25R)-24,26-dihydroxycholesterolReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. (24S)-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S,25R)-24,26-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by DHCR24, CYP46A1endoplasmic reticulum

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by DHCR24, SOAT2, SOAT1, HADHA and 2 moreendoplasmic reticulum, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. 24-Dehydrocholesterol Reductase [Precursor]
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by DHCR24, SOAT2, SOAT1, SLC27A2 and 7 moreendoplasmic reticulum, cytosolOne of 4 routes