sulfite

Three steps

• (R)-noradrenalineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• CHEBI:730073Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by TSTD1, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• (2S)-2-aminobutanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 6 routes

• 2-iminobutanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by MPST, TST, AGXT2, RIDAcytosol

• 2-aminoprop-2-enoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. D-serine = pyruvate + NH4(+)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by MPST, TST, SRRcytosol

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• beta-citrylglutamateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial
  3. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)

  Catalysed by SLC25A10, SLC25A1, RIMKLBmitochondrial matrix, cytosol

• ursodeoxycholateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• prostaglandin G2Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• an alkyl sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. an alcohol + 3'-phosphoadenylyl sulfate = an alkyl sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TSTD1, CP, PRDX6, SULT2B1 and 2 more

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SUOX, STS, CYP3A7mitochondrial matrix, cytosol

• 3-methylmalateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by SLC25A10, CLYBLmitochondrial matrix, cytosol

• thromboxane B2Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 13-oxo-(9Z,11E)-octadecadienoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O

  Catalysed by SUOX, CYP1A1, CYP1A2, CYP1B1 and 2 moremitochondrial matrix, cytosol

• (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by TSTD1, PTGES, MGST3, GPX1 and 4 more

• (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by TSTD1, PTGES, MGST3, GPX1 and 4 more

• (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by TSTD1, PTGES, MGST3, GPX1 and 4 more

• thiamine(1+) diphosphateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by MPST, TST, PDHA1, PDHB and 2 morecytosol, mitochondrial matrix