1-phosphatidyl-1D-myo-inositol

Three steps

• CHEBI:63544Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 7 routes

• (4R)-hydroxysphinganineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. Phytoceramide amidohydrolase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 17 morecytosolOne of 2 routes

• a 1-acyl-sn-glycero-3-phospho-L-serineReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 7 morecytosol, inner side of the membrane, outer side of the membrane

• a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 13 morecytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 13 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 22 morecytosol

• hexacosanoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 5 routes

• a 2-acyl-sn-glycero-3-phospho-D-myo-inositolReach from here →
  1. Phospholipase D
  2. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)

  Catalysed by PLD2, CDIPT, DDHD1cytosol

• a 2-acyl-sn-glycerol 3-phosphateReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 22 morecytosolOne of 2 routes

• tetracosanoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 9 routes

• a 2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 13 morecytosolOne of 2 routes

• a 2-acyl-sn-glycero-3-phospho-L-serineReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
  3. a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 9 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylsphinganine-1-phosphocholineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 12 morecytosolOne of 2 routes

• (22R)-hydroxycholesterolReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (22R)-hydroxycholesterol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 11 morecytosol, extracellular spaceOne of 12 routes

• N-dodecanoylsphing-4-enineReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-hexadecanoylsphing-4-enineReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membrane

• N-octadecanoylsphing-4-enineReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membrane

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 9 routes

• an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 13 morecytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 5 routes

• N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
  1. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + cholesterol(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + cholesterol(out)
  3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by PI4KA, PI4K2B, PI4K2A, PI4KB and 2 morecytosol, inner side of the membrane, outer side of the membrane

• nonadecanoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosolOne of 3 routes

• a 2,3-diacyl-sn-glycerolReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA
  3. a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 17 morecytosolOne of 2 routes

• 1-O-alkyl-3-acylglycerolReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 13 morecytosolOne of 2 routes

• dodecanedioyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 15 morecytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Production of Suberylcarnitine

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 15 morecytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 23 morecytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. phosphoinositide phospholipase C (PI pool)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by PLCH2, PLCG2, PLCG1, PLCD1 and 18 morecytosol