choline

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

807 compounds within 3 steps: 8 in 1, 196 in 2, 603 in 3

Two steps

(2E)-octadecenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Carnitine O-Palmitoyltransferase
Catalysed by CHAT, CPT1A, CPT1C, CPT1BcytosolOne of 3 routes
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (DPA)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 6 routes
(9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (linolenate)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes
(13Z)-docosenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 6 routes
(11Z)-eicosenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes
nonadecanoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by CHAT, CPT1A, CPT1C, CPT1BcytosolOne of 3 routes
dodecanedioyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Activation of dodecanedioic acid
Catalysed by CHATcytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Production of Sebacoylcarnitine
Catalysed by CHAT, CPT1A, CPT1C, CPT1BcytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Production of Suberylcarnitine
Catalysed by CHAT, CPT1A, CPT1C, CPT1BcytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by CHATcytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by CHAT, CPT1A, CPT1C, CPT1Bcytosol
(13Z)-eicosenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by CHAT, CRAT, CROTcytosol, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by CHAT, ACAA1, HSD17B4, EHHADH and 1 morecytosol, peroxisome
hexadecanedioyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Production of Hexadecanedioylcarnitine
Catalysed by CHAT, CPT1A, CPT1C, CPT1BcytosolOne of 2 routes
pristanoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. fatty-acid-CoA ligase
Catalysed by CHAT, SLC27A2cytosolOne of 2 routes
undecanoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by CHAT, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 3 routes
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by CHDH, PTGS1, PTGS2
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by CHDH, PTGS1, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by CHDH, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by CHDH, PTGS2
thio-Mo-molybdopterinReach from here →
1. choline + A = betaine aldehyde + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by CHDH, MOCOS
(5Z)-tetradecenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by CHAT, ACADM, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrix
2-glyceryl-prostaglandin H2Reach from here →
1. choline + A = betaine aldehyde + AH2
2. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by CHDH, PTGS2
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by CHAT, HADHA, ACAA2, HADHBcytosol, mitochondrial matrix
(7Z)-hexadecenoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes
tricosanoyl-CoAReach from here →
1. Acetyl-CoA:choline O-acetyltransferase
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by CHAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 4 routes
prostaglandin H1Reach from here →
1. choline + A = betaine aldehyde + AH2
2. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by CHDH, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by CHDH, PTGS2
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by CHDH, PTGS2
(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by CHDH, PTGS2
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by CHDH, PTGS2
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by CHDH, PTGS2
(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. choline + A = betaine aldehyde + AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by CHDH, PTGS2