15-oxoprostaglandin F2alpha

Three steps

• dopamineReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (2S)-2-phospholactateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + 2 (S)-lactate(in) = prostaglandin F2alpha(in) + 2 (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by SLCO2A1, PGPcytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• N-benzoylglycineReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-cysteinylglycineReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLCO2A1, GGTLC3, GGT1, GGT5 and 3 morecytosol, extracellular spaceOne of 4 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHB, LDHAL6B, HOGA1extracellular space, cytosol, mitochondrial matrix

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by LDHB, LDHAL6B, HOGA1extracellular space, cytosol, mitochondrial matrix

• (R)-noradrenalineReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• CHEBI:730073Reach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC22A12, MPOextracellular space, cytosol, nucleusOne of 3 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• ursodeoxycholateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLC22A8, SLC22A24cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11beta-prostaglandin F2Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. aldo-keto reductase (prostaglandin D2)
  3. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

  Catalysed by AKR1C3, AKR1C2cytosol

• (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

  Catalysed by TBXAS1, CYP2S1, PTGES2cytosol

• thromboxane B2Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 6 routes

• 19-hydroxyprostaglandin H2Reach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CYP4F8cytosol

• taurochenodeoxycholateReach from here →
  1. 15-keto-prostaglandin F2alpha reduction
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by LDHB, LDHAL6B, PDHA1, PDHB and 1 moreextracellular space, cytosol, mitochondrial matrix