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Proteins/UNIPROT:Q9UI33
Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization..
Function from UniProtKB (Q9UI33), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
12 statements
12 statements · 5 reference databases · Subject: SCN11A · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
Transported by SCN1A or SCN2A or SCN3A or SCN4A or SCN5A or SCN7A or SCN8A or SCN9A or SCN10A or SCN11A or HCN1 or HCN4 and 5 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01527CC BY 4.0Reference data
8 names
Resolves to: SCN11A
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data