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Proteins/UNIPROT:Q9UQD0
Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation..
[Isoform 5]: More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement..
Function from UniProtKB (Q9UQD0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 rows
19 statements
19 statements · 5 reference databases · Subject: SCN8A · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
Transported by SCN1A or SCN2A or SCN3A or SCN4A or SCN5A or SCN7A or SCN8A or SCN9A or SCN10A or SCN11A or HCN1 or HCN4 and 5 more alternatives
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01527CC BY 4.0Reference data
3 names
Resolves to: SCN8A
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:34963CC BY 4.0Reference data