Proteins/UNIPROT:Q9Y6I3

EPN1

ProteinUNIPROT:Q9Y6I3

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis..

Function from UniProtKB (Q9Y6I3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

39 statements

39 statements · 4 reference databases · Subject: EPN1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

EPN1 covaries with PAQR5ProteinHetionet hetionet:covaries:29924-54852Inferred only
AP1M2 interacts with EPN1ProteinHetionet hetionet:interacts:10053-29924Inferred only
AP2A1 interacts with EPN1ProteinHetionet hetionet:interacts:160-29924Inferred only
AP2A2 interacts with EPN1ProteinHetionet hetionet:interacts:161-29924Inferred only
BCAR1 interacts with EPN1ProteinHetionet hetionet:interacts:29924-9564Inferred only
CDK1 interacts with EPN1ProteinHetionet hetionet:interacts:29924-983Inferred only
EPN1 interacts with CEP126ProteinHetionet hetionet:interacts:29924-57562Inferred only
CLTC interacts with EPN1ProteinHetionet hetionet:interacts:1213-29924Inferred only
CRMP1 interacts with EPN1ProteinHetionet hetionet:interacts:1400-29924Inferred only
DLL1 interacts with EPN1ProteinHetionet hetionet:interacts:28514-29924Inferred only
EGFR interacts with EPN1ProteinHetionet hetionet:interacts:1956-29924Inferred only
EPS15 interacts with EPN1ProteinHetionet hetionet:interacts:2060-29924Inferred only

Show the remaining 27

EPN1 interacts with EPS15L1ProteinHetionet hetionet:interacts:29924-58513Inferred only
GTF3A interacts with EPN1ProteinHetionet hetionet:interacts:2971-29924Inferred only
ITGA4 interacts with EPN1ProteinHetionet hetionet:interacts:29924-3676Inferred only
KDR interacts with EPN1ProteinHetionet hetionet:interacts:29924-3791Inferred only
LAPTM5 interacts with EPN1ProteinHetionet hetionet:interacts:29924-7805Inferred only
EPN1 interacts with MED31ProteinHetionet hetionet:interacts:29924-51003Inferred only
NOTCH1 interacts with EPN1ProteinHetionet hetionet:interacts:29924-4851Inferred only
PSMD4 interacts with EPN1ProteinHetionet hetionet:interacts:29924-5710Inferred only
REPS2 interacts with EPN1ProteinHetionet hetionet:interacts:29924-9185Inferred only
RNF11 interacts with EPN1ProteinHetionet hetionet:interacts:26994-29924Inferred only
SCNN1A interacts with EPN1ProteinHetionet hetionet:interacts:29924-6337Inferred only
SCNN1B interacts with EPN1ProteinHetionet hetionet:interacts:29924-6338Inferred only
SCNN1G interacts with EPN1ProteinHetionet hetionet:interacts:29924-6340Inferred only
UBC interacts with EPN1ProteinHetionet hetionet:interacts:29924-7316Inferred only
VCAM1 interacts with EPN1ProteinHetionet hetionet:interacts:29924-7412Inferred only
ZBTB16 interacts with EPN1ProteinHetionet hetionet:interacts:29924-7704Inferred only
EPN1 participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
EPN1 participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
EPN1 participates in EGF EGFR signalingPathwayWikiPathways WP437Inferred only
EPN1 participates in EGFR downregulationPathwayReactome R-HSA-182971Inferred only
EPN1 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
EPN1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
EPN1 participates in Signaling by EGFRPathwayReactome R-HSA-177929Inferred only
EPN1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
EPN1 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
EPN1 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
EPN1 regulates negative regulation of sprouting angiogenesisBiological processgene ontology Q9Y6I3|GO:1903671Inferred only

Other names

2 names

Resolves to: EPN1

Also called: EH domain-binding mitotic phosphoproteinEPS-15-interacting protein 1

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