Pathway
Glyoxylate metabolism and glycine degradation
Glyoxylate is generated in the course of glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. Defects in two enzymes of glyoxylate metabolism, alanine:glyoxylate aminotransferase (AGXT) and glycerate dehydrogenase/glyoxylate reductase (GRHPR), are associated with pathogenic overproduction of oxalate. The reactions that interconvert glycine, glycolate, and glyoxylate and convert glyoxylate to oxalate have been characterized in molecular detail in humans. A reaction sequence for the conversion of hydroxyproline to glyoxylate has been inferred from studies of partially purified extracts of rat and bovine liver but the enzymes involved in the corresponding human reactions have not been identified.
What the reference databases state
Statements
19 statements
19 statements · 1 reference database · Subject: Glyoxylate metabolism and glycine degradation · Sources: Reactome
- AGXT participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- AGXT2 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- ALDH4A1 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- AMT participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- DAO participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- DDO participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- DLD participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- DLST participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- GCSH participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- GLDC participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- GNMT participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- GOT2 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
Show the remaining 7
- GRHPR participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- HAO1 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- HOGA1 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- KGD4 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- OGDH participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- PRODH2 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only
- PXMP2 participates in Glyoxylate metabolism and glycine degradationProteinReactome R-HSA-389661Inferred only