Pathway
Abacavir metabolism
Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body.
REACT:R-HSA-2161541Reactome
What the reference databases state
Statements
4 statements
4 statements · 1 reference database · Subject: Abacavir metabolism · Sources: Reactome
- ADH1A participates in Abacavir metabolismProteinReactome R-HSA-2161541Inferred only
- MAPDA participates in Abacavir metabolismProteinReactome R-HSA-2161541Inferred only
- NT5C2 participates in Abacavir metabolismProteinReactome R-HSA-2161541Inferred only
- PCK1 participates in Abacavir metabolismProteinReactome R-HSA-2161541Inferred only