cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate

Three steps

• glycolithocholate 3-sulfateReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by CEL, LIPA, SLCO1B1, SLCO1A2 and 1 morelysosome, extracellular space, cytosolOne of 4 routes

• a 2,3-dehydroacyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by CEL, LIPA, PTGS1, PTGS2 and 1 morelysosome

• estrone 3-sulfateReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by CEL, LIPA, SLCO1B1lysosome, extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by CEL, LIPA, SLCO1B1, SLCO1A2 and 1 morelysosome, extracellular space, cytosolOne of 7 routes

• decanoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 6 morelysosome, endoplasmic reticulum, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 11 routes

• L-cysteinylglycineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by CEL, LIPA, GGTLC3, GGT1 and 4 morelysosome, extracellular space, cytosolOne of 4 routes

• Fe(II)-heme aReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

  Catalysed by CEL, LIPA, PTGS1, PTGS2 and 1 morelysosome

• 3-hydroxyisovaleryl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 2 morelysosome, endoplasmic reticulum, cytosol

• CHEBI:63544Reach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Arachidonate:CoA ligase (AMP-forming)
  3. fatty-acyl-CoA elongation (N-C20:4CoA)

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 10 morelysosome, cytosolOne of 8 routes

• pregn-5-ene-3,20-dioneReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. cytochrome P450 (cholesterol)
  3. Pregnenolone:NAD+ 3-oxidoreductase

  Catalysed by CEL, LIPA, CYP11A1, HSD3B1 and 1 morelysosome, mitochondrial matrix, cytosolOne of 2 routes

• 4-methylpentan-1-olReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. cytochrome P450 (cholesterol)
  3. aldose reductase (isocaproic-aldehyde)

  Catalysed by CEL, LIPA, CYP11A1, AKR1B10 and 1 morelysosome, mitochondrial matrix, cytosolOne of 2 routes

• hexacosanoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 9 routes

• 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O

  Catalysed by CEL, LIPA, ALOX5, CYP1A1 and 3 morelysosome

• Mo-molybdopterinReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CEL, LIPA, PTGS1, PTGS2 and 1 morelysosome

• (2E)-octadecenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 8 routes

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CEL, LIPAlysosome, cytosol, extracellular spaceOne of 15 routes

• (R)-noradrenalineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. transport of arachidonate (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by CEL, LIPA, SLCO1B1, SLCO1A2 and 1 morelysosome, extracellular space, cytosolOne of 4 routes

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositolReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 10 morelysosome

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 11 morelysosome

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + (24S)-hydroxycholesterol = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by CEL, LIPA, CYP46A1, LCATlysosome, endoplasmic reticulumOne of 2 routes

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 11 morelysosome

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 10 morelysosome

• (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + malonyl-CoA + H(+) = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 12 morelysosome

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 5 routes

• 1-heptadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by CEL, LIPA, ABHD16Alysosome

• 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 12 morelysosome

• 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 12 morelysosome

• 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphateReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 15 morelysosome

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. Arachidonate:CoA ligase (AMP-forming)
  3. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 10 morelysosome, cytosolOne of 2 routes

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 10 morelysosome

• 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. sterol esterase (Cholesteryl Arachidonate)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-dodecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 10 morelysosome