dodecanedioyl-CoA

Three steps

• N-(tetradecanoyl)-sphinganineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 3-oxohexadecasphinganineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 3-oxotetradecasphinganineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• Mo-molybdopterinReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by ACOT8, MOCOSperoxisome, mitochondrial matrix

• 3-oxooctadecanoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Palmitate:CoA ligase (AMP-forming)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 12 moreperoxisome, cytosolOne of 2 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 12 moreperoxisome, cytosolOne of 3 routes

• 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
  3. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by ACOT8, CPT1A, CPT1C, CPT1Bperoxisome, cytosol, endoplasmic reticulumOne of 2 routes

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosolOne of 2 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• N-dodecanoylsphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by ACOT8, ASAH1, ACER2, ACER1 and 2 moreperoxisome, Golgi apparatus

• N-tetradecanoylsphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by ACOT8, ASAH1, ACER2, ACER1 and 1 moreperoxisome, Golgi apparatus

• N-hexadecanoylsphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by ACOT8, ASAH1, ACER2, ACER1 and 5 moreperoxisome, Golgi apparatusOne of 2 routes

• N-octadecanoylsphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosolOne of 3 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 2 routes

• N-tetracosanoyl-sphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 2 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosol

• (9Z,12Z)-octadecadien-1-olReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (DPA)
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 3-oxooctacosanyol-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• 3-oxotetracosanoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 12 moreperoxisome, cytosolOne of 3 routes

• 3-oxohexacosanoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 12 moreperoxisome, cytosolOne of 3 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosol

• (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosol

• 3-oxo-(13Z)-docosenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
  3. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 3-oxo-(15Z)-tetracosenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
  3. (13Z)-docosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z)-tetracosenoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosol

• N-(15Z-tetracosenoyl)-sphinganineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)
  3. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• N-tetracosanoyl-heptadecasphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. heptadecasphing-4-enine + tetracosanoyl-CoA = N-tetracosanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• (2E)-hexacosenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. acyl-CoA oxidase (hexacosanoyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 2 routes

• 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoAReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
  3. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosol

• (2S)-2-aminobutanoateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by ACOT8, GLYAT, GLYATL2, GLYATL1 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes

• N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine

  Catalysed by ACOT8, ASAH1, ACER2, ACER1 and 1 moreperoxisome, Golgi apparatus

• N-(tetracosenoyl)-sphing-4-enineReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. acyl-CoA:sphingosine N-acyltransferase
  3. tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)

  Catalysed by ACOT8, ASAH1, ACER2, ACER1 and 2 moreperoxisome, Golgi apparatus

• 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 9 moreperoxisome, cytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 10 moreperoxisome, cytosol

• 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  2. long-chain-fatty-acid-CoA ligase (margaric acid)
  3. heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT8, SLC27A2, ACSL4, ACSL3 and 10 moreperoxisome, cytosol