N(8)-acetylspermidine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

248 compounds within 3 steps: 2 in 1, 33 in 2, 213 in 3

Three steps

(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
nonadecanoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 3 routes
1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 8 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 2 routes
1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 5 routes
2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-octadecanoyl-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 9 routes
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 2 routes
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 3 routes
2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 3 routes
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15
2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
16alpha,17alpha-dihydroxyprogesteroneReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. cytochrome P450 (17alpha-hydroxyprogesterone)
3. 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by HDAC10, CYP17A1endoplasmic reticulum
dodecanedioyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Activation of dodecanedioic acid
Catalysed by SAT1, SAT2cytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Production of Sebacoylcarnitine
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Production of Suberylcarnitine
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by SAT1, SAT2cytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosol
(13Z)-eicosenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by SAT1, SAT2, CRAT, CROTcytosol, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by SAT1, SAT2, ACAA1, HSD17B4 and 2 morecytosol, peroxisome
hexadecanedioyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Production of Hexadecanedioylcarnitine
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosolOne of 2 routes
pristanoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. fatty-acid-CoA ligase
Catalysed by SAT1, SAT2, SLC27A2cytosolOne of 2 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
Catalysed by HDAC10, ASAH1, PLA2G15
undecanoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by SAT1, SAT2, ACSM4, ACSM1 and 4 morecytosolOne of 3 routes
1-octadecanoyl-sn-glycero-3-phosphoserineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by HDAC10, ASAH1, PLA2G15
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by HDAC10, ASAH1, PLA2G15One of 8 routes
(5Z)-tetradecenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by SAT1, SAT2, ACADM, ECHS1 and 2 morecytosol, mitochondrial matrix
N-(acetyl)-sphing-4-enine-1-phosphateReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
3. N-(acetyl)-sphing-4-enine + ATP = N-(acetyl)-sphing-4-enine-1-phosphate + ADP + H(+)
Catalysed by HDAC10, ASAH1, CERK
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by SAT1, SAT2, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrix
(7Z)-hexadecenoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes
tricosanoyl-CoAReach from here →
1. N8-acetylspermidine to spermidine conversion
2. diamine N-acetyltransferase (N1-acetylspermidine)
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 6 morecytosolOne of 4 routes
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. N(8)-acetylspermidine + H2O = spermidine + acetate
2. transport of acetate and pyruvate (cytosol to extracellular)
3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by HDAC10, SLC16A4, SLC16A5, SLC16A3 and 5 moreextracellular space, cytosol, mitochondrial matrix