(9Z)-octadecenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

639 compounds within 3 steps: 12 in 1, 130 in 2, 497 in 3

Three steps

monodehydro-L-ascorbate radicalReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
3. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 7 more
4-aminobutanoateReach from here →
1. Utilized Transport
2. Carnitine Transport by Atb0
3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
Catalysed by SLC6A14, SLC6A12endoplasmic reticulum, cytosol, extracellular spaceOne of 4 routes
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
3. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol
sphing-4-enine 1-phosphateReach from here →
1. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
2. H2O[r] + N-(9Z-octadecenoyl)-sphing-4-enine[r] = oleate[r] + sphingosine[r]
3. sphing-4-enine + ATP = sphing-4-enine 1-phosphate + ADP + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 3 moreendoplasmic reticulum
(9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
3. linoleate:oxygen 9-oxidoreductase
No catalyst recordedcytosol, extracellular space
decanoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. medium-chain acyl-CoA ligase (decanoic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 13 morecytosolOne of 8 routes
(2E)-hexadecenoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. Carnitine O-Palmitoyltransferase
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 6 routes
(9Z)-hexadecenoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. long-chain-fatty-acid-CoA ligase (palmitolate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 17 routes
a cardiolipinReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. acyl-CoA pool formation and breakdown
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol
(2E)-octenoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Beta Oxidation Fatty Acid
3. trans-oct-2-enoyl-CoA reductase
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosol, mitochondrial matrixOne of 5 routes
3-hydroxyisovaleryl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosol
an all-trans-retinyl esterReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. acyl-CoA pool formation and breakdown
3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 morecytosol
CHEBI:63544Reach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. long-chain-fatty-acid-CoA ligase (adrenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 10 routes
18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
3. cytochrome P450 (arachidonate)
Catalysed by CYP4F8cytosol, extracellular space, endoplasmic reticulumOne of 2 routes
1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
3. 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreOne of 2 routes
hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 9 more
a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. acyl-CoA pool formation and breakdown
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 morecytosol
a triacyl-sn-glycerolReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. acyl-CoA pool formation and breakdown
3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 10 morecytosol
a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. acyl-CoA pool formation and breakdown
3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosol
hexacosanoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. long-chain-fatty-acid-CoA ligase (cerotic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 9 routes
tetracosanoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. long-chain-fatty-acid-CoA ligase (lignocerate)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 17 routes
1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositolReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 7 more
docosanoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. long-chain-fatty-acid-CoA ligase (behenic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 14 routes
3-oxoeicosasphinganineReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 9 more
3-oxoeicosanoyl-CoAReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 13 morecytosolOne of 2 routes
N-(octadecanoyl)-sphinganineReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 12 more
an N-acylsphinganine-1-phosphocholineReach from here →
1. (10Z)-heptadecenoic acid formation
2. N-acylsphingosine amidohydrolase
3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 3 morecytosol
(22R)-hydroxycholesterolReach from here →
1. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
2. beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (22R)-hydroxycholesterol + 2 oxidized [adrenodoxin] + H2O
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 moreOne of 2 routes
(2E)-octadecenoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. Carnitine O-Palmitoyltransferase
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 10 routes
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. long-chain-fatty-acid-CoA ligase (stearidonic acid)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 9 routes
1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 7 more
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositolReach from here →
1. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA
Catalysed by ABHD16A, LCLAT1
1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)
2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by ABHD16A, LCLAT1
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 7 moreOne of 2 routes
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosolOne of 2 routes
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 8 more
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 7 more
N-dodecanoylsphing-4-enineReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
Catalysed by NAAA, ASAH1, ACER2, ASAH2cytosol, extracellular spaceOne of 4 routes
N-tetradecanoylsphing-4-enineReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate
Catalysed by ASAH1, ACER2, ASAH2cytosol, extracellular spaceOne of 2 routes
N-hexadecanoylsphing-4-enineReach from here →
1. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
2. H2O[r] + N-(9Z-octadecenoyl)-sphing-4-enine[r] = oleate[r] + sphingosine[r]
3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 5 moreendoplasmic reticulumOne of 3 routes
N-octadecanoylsphing-4-enineReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
3. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate
Catalysed by ASAH1, ACER2, ASAH2cytosol, extracellular spaceOne of 5 routes
N-eicosanoyl-sphing-4-enineReach from here →
1. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
2. H2O[r] + N-(9Z-octadecenoyl)-sphing-4-enine[r] = oleate[r] + sphingosine[r]
3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 3 moreendoplasmic reticulum
N-tetracosanoyl-sphing-4-enineReach from here →
1. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
2. H2O[r] + N-(9Z-octadecenoyl)-sphing-4-enine[r] = oleate[r] + sphingosine[r]
3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 2 moreendoplasmic reticulum
1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 10 moreOne of 17 routes
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 7 more
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 morecytosol
1-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
2. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 7 moreOne of 2 routes
(9Z,12Z)-octadecadien-1-olReach from here →
1. long-chain-fatty-acid-CoA ligase (oleate)
2. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoAReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
3. (7Z,10Z,13Z,16Z)-docosatetraenoate + ATP + CoA = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AMP + diphosphate
Catalysed by ACSL4cytosol, extracellular space