O-octanoyl-(R)-carnitine

Three steps

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. linoleate:oxygen 9-oxidoreductase

  Catalysed by SLC25A20mitochondrial matrix, cytosol, endoplasmic reticulum

• (2E)-decenoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. fatty acyl-CoA synthase (N-C10:0CoA)
  3. trans-dec-2-enoyl-CoA reductase

  Catalysed by CROT, MECRmitochondrial matrix, cytosolOne of 5 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 6 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 16 routes

• (2E)-hexenoyl-CoAReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Fatty Acid Beta Oxidation (C8->C6), Peroxisomal
  3. trans-hex-2-enoyl-CoA reductase

  Catalysed by CROT, ACAA1, HSD17B4, EHHADH and 2 moremitochondrial matrix, peroxisomeOne of 3 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol

• CHEBI:63544Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 7 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. cytochrome P450 (arachidonate)

  Catalysed by SLC25A20, CYP4F8mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• hexacosanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 9 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 8 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by SLC25A20, ABHD12mitochondrial matrix, cytosol, endoplasmic reticulum

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by SLC25A20, ABHD16Amitochondrial matrix, cytosol, endoplasmic reticulum

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 9 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 7 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX12Bmitochondrial matrix, cytosol, endoplasmic reticulum

• 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. fatty acyl-CoA synthase (N-C10:0CoA)
  3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CROT, LPCAT1mitochondrial matrix, cytosol

• (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. Arachidonate:oxygen 8-oxidoreductase

  Catalysed by SLC25A20, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. fatty acid amide hydrolase (arachidonate)

  Catalysed by SLC25A20, FAAHmitochondrial matrix, cytosol, endoplasmic reticulum

• dodecanedioyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Production of Suberylcarnitine

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. arachidonic acid:oxygen 1-oxidoreductase

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2E1 and 24 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP2C9mitochondrial matrix, cytosol, endoplasmic reticulum

• 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A20, CYP1A1, CYP1A2, CYP2C9 and 2 moremitochondrial matrix, cytosol, endoplasmic reticulum

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 4 routes

• tetradecanedioyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 4 moremitochondrial matrix, cytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes