O-hexadecanoyl-(R)-carnitine

Three steps

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, LPCAT3 and 2 more

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 7 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by CPT2, CPT1A, SCD, MBOAT2peroxisome, cytosolOne of 2 routes

• 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT2, CPT1A, SCD, MBOAT2peroxisome, cytosol

• 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT2, CPT1A, SCD, LPCAT3 and 1 moreperoxisome, cytosol

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 10 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 5 routes

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by CPT2, CPT1A, PHYHperoxisome, cytosol

• (15Z)-tetracosenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 8 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 6 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by CPT2, CPT1A, GPAT3, LCLAT1 and 4 moreperoxisome, cytosol

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by CPT2, CPT1A, GPAT3, GPAT2 and 2 moreperoxisome, cytosolOne of 2 routes

• 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by CPT2, CPT1A, HADHA, ACADVL and 6 moreperoxisome, mitochondrial matrix

• 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by CPT2, CPT1A, CPT1B, LPGAT1 and 1 more

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by CPT2, CPT1A, SCD, AGPAT1peroxisome, cytosol

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z)-hexadecenoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by CPT2, CPT1A, SCD, MBOAT1peroxisome, cytosol

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by CPT2, CPT1A, MBOAT1, LPGAT1peroxisome, cytosol

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT2, CPT1A, LPGAT1peroxisome, cytosol

• 1-hexadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, LPGAT1 and 3 more

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT2, CPT1A, LPGAT1peroxisome, cytosol

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT2, CPT1A, LPGAT1peroxisome, cytosol

• nonadecanoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by CPT2, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes

• 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, LCLAT1 and 6 more

• 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by CPT2, CPT1A, LCLAT1peroxisome, cytosol

• (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by CPT2, CPT1A, ALOX12Bperoxisome, endoplasmic reticulum, cytosol

• 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Beta Oxidation of Long Chain Fatty Acid
  3. octanoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT2, CPT1A, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT2, CPT1A, LPCAT4peroxisome, cytosol

• 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Beta Oxidation of Long Chain Fatty Acid
  3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT2, CPT1A, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT2, CPT1A, HADHA, ACADVL and 2 moreperoxisome, mitochondrial matrix

• (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. Arachidonate:oxygen 8-oxidoreductase

  Catalysed by CPT2, CPT1A, ALOX12peroxisome, endoplasmic reticulum, cytosolOne of 2 routes

• a 2,3-diacyl-sn-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by CPT2, CPT1A, MOGAT2, MOGAT1peroxisome, cytosol

• 1-hexadecanoyl-sn-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate

  Catalysed by CPT2, CPT1A, GPAT3, GPAT2 and 3 moreperoxisome, cytosol

• 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerolReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
  3. 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, DGAT1 and 3 more

• 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
  3. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT2, CPT1A, HADHA, ACADVL and 3 moreperoxisome, mitochondrial matrix

• 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT2, CPT1A, MOGAT2, MOGAT1peroxisome, cytosol

• hexadecyl (9Z)-octadecenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. formate dehydrogenase (palmitoyl-CoA)
  3. hexadecan-1-ol + (9Z)-octadecenoyl-CoA = hexadecyl (9Z)-octadecenoate + CoA

  Catalysed by CPT2, CPT1A, FAR1, FAR2 and 2 moreperoxisome

• hexadecyl (9Z)-hexadecenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. hexadecan-1-ol + (9Z)-hexadecenoyl-CoA = hexadecyl (9Z)-hexadecenoate + CoA

  Catalysed by CPT2, CPT1A, SCD, AWAT1 and 1 moreperoxisome, cytosolOne of 2 routes

• hexadecyl octadecanoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. formate dehydrogenase (palmitoyl-CoA)
  3. hexadecan-1-ol + octadecanoyl-CoA = hexadecyl octadecanoate + CoA

  Catalysed by CPT2, CPT1A, FAR1, FAR2 and 2 moreperoxisomeOne of 2 routes

• 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerolReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
  3. 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, DGAT1 and 3 more