palmitoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

829 compounds within 3 steps: 17 in 1, 232 in 2, 580 in 3

Three steps

(22S)-22-hydroxycholesterolReach from here →
1. Acyl-CoA:cholesterol O-acyltransferase
2. Steryl-ester acylhydrolase
3. cytochrome P450 (cholesterol)
Catalysed by SOAT2, SOAT1, CEL, LIPA and 2 moreendoplasmic reticulum, lysosome, mitochondrial matrix
AReach from here →
1. Palmitoyl-CoA hydrolase
2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, mitochondrial matrixOne of 3 routes
(5E)-tetradecenoyl-(R)-carnitineReach from here →
1. Palmitoyl-CoA hydrolase
2. Carnitine O-Palmitoyltransferase
3. carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 7 routes
S-butanoyl-4'-phosphopantetheineReach from here →
1. Palmitoyl-CoA hydrolase
2. Butanoate:CoA ligase (AMP-forming)
3. butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
decanoyl-4'-phosphopantetheineReach from here →
1. Palmitoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (decanoic acid)
3. decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosol
S-dodecanoyl-4'-phosphopantetheineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol
S-hexadecanoyl-4'-phosphopantetheineReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by SCD, SCD5, NUDT19, FITM2cytosol
21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. DHA[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate[r]
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 2 morecytosol, endoplasmic reticulumOne of 3 routes
tauroursodeoxycholateReach from here →
1. Palmitoyl-CoA hydrolase
2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
3. taurine to tauroursodeoxycholate conversion
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes
glycoursodeoxycholateReach from here →
1. Palmitoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. glycine to glycoursodeoxycholate conversion
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes
13-hydroxytetradecanoateReach from here →
1. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
2. Myristoyl-CoA hydrolase
3. myristic acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 13-hydroxytetradecanoate[r]
Catalysed by HADHA, ACADVL, HADHB, ACOT7 and 5 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes
1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerolReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA
Catalysed by SCD, SCD5, MOGAT2, MOGAT1cytosol
leukotriene F4Reach from here →
1. Palmitoyl-CoA hydrolase
2. N-acetyl-LTE4 to leukotriene E4 conversion
3. leukotriene F4 hydrolysis
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 33 morecytosol
(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 3 morecytosol
19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 3 morecytosol
16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 3 morecytosol
13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 3 morecytosol
10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 3 morecytosol
2,4-dinitrophenyl-S-glutathioneReach from here →
1. Palmitoyl-CoA hydrolase
2. N-acetyl-LTE4 to leukotriene E4 conversion
3. transport of leukotriene E4 (cytosol to extracellular)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 34 morecytosol, extracellular spaceOne of 2 routes
N-(9Z-octadecenoyl)glycineReach from here →
1. Palmitoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes
(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 8 morecytosol
(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 7 morecytosol
cholesterol sulfateReach from here →
1. Acyl-CoA:cholesterol O-acyltransferase
2. Steryl-ester acylhydrolase
3. 3'-phosphoadenylyl-sulfate:cholesterol sulfotransferase
Catalysed by SOAT2, SOAT1, CEL, LIPA and 2 moreendoplasmic reticulum, lysosome, cytosolOne of 3 routes
2-hydroxydecanoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (decanoic acid)
3. decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosol
2-hydroxyeicosanoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
2-hydroxydodecanoyl-CoAReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
13-cis-retinyl hexadecanoateReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA
Catalysed by SCD, SCD5, DGAT1cytosol
1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
9-cis-retinyl hexadecanoateReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 9-cis-retinol + hexadecanoyl-CoA = 9-cis-retinyl hexadecanoate + CoA
Catalysed by SCD, SCD5, AWAT2cytosol
1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerolReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA
Catalysed by SCD, SCD5, DGAT1, MOGAT2 and 1 morecytosol
N-hexadecanoylglycineReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
Catalysed by SCD, SCD5, GLYATL3cytosolOne of 2 routes
N-dodecanoylglycineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes
N-decanoylglycineReach from here →
1. Palmitoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (decanoic acid)
3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosolOne of 2 routes
N-octanoyl-(2S)-hydroxyglycineReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
3. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
Catalysed by ACADM, ACADS, GLYATL2, PAMmitochondrial matrix
N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
1. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
Catalysed by HADHA, ACADVL, HADHB, GLYATL2 and 1 moremitochondrial matrix
N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
1. Palmitoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix
L-cystine-bis-glycineReach from here →
1. Palmitoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, mitochondrial matrix
a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
1. acyl-CoA pool formation and breakdown
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
3. a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol
Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol
a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
1. acyl-CoA pool formation and breakdown
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
3. a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol
Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol
a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
1. acyl-CoA pool formation and breakdown
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
3. a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol
Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol
a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
1. acyl-CoA pool formation and breakdown
2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
3. a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol
Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol
an N-hexadecanoyl-sphingoid baseReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)
Catalysed by SCD, SCD5, CERS6, CERS5cytosol
glycyldehydrophenylalanineReach from here →
1. Palmitoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix
1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. fatty-acyl-CoA synthase (N-C18:0CoA)
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, ALOX15Bcytosol
1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerolReach from here →
1. Palmitoyl-CoA:retinol O-acyltransferase
2. 11-peroxy-docosahexaenoate to DHA conversion
3. 1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)
Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 2 morecytosol
N-hexadecanoyl-sphinga-4E,14Z-dienineReach from here →
1. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. sphinga-4E,14Z-dienine + hexadecanoyl-CoA = N-hexadecanoyl-sphinga-4E,14Z-dienine + CoA + H(+)
Catalysed by SCD, SCD5, CERS6, CERS5cytosol
an N-(fatty acyl)-glycineReach from here →
1. Palmitoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrix
1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
1. Palmitoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes
cholesteryl (7Z)-octadecenoateReach from here →
1. Palmitoyl-CoA hydrolase
2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol