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Proteins/UNIPROT:P36021
Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT)..
Function from UniProtKB (P36021), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
99 statements
99 statements · 6 reference databases · Subject: SLC16A2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
Transported by SLCO4A1 or SLCO1B1 or SLCO1C1 or SLC16A2 or SLCO3A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06055CC BY 4.0Reference data
3,3',5-triiodo-L-thyronine3,3',5-triiodo-L-thyronine
Transported by SLC16A2
Reaction pageReversibleBalancedcytosol, extracellular space
8 names
Resolves to: SLC16A2
3,3',5-triiodo-L-thyronine3,3',5-triiodo-L-thyronine
Transported by SLC16A2 or SLC7A5 or SLCO4C1 or SLC16A10 or SLCO4A1 or SLCO1C1 or SLC7A8 or SLC17A4
Reaction pageReversibleBalanced
Rhea RHEA:71811CC BY 4.0Reference data
3,3',5'-triiodo-L-thyronine3,3',5'-triiodo-L-thyronine
Transported by SLC16A2 or SLCO1A2 or SLC7A5 or SLCO4A1 or SLCO1C1 or SLCO1B1
Reaction pageLeft to rightBalanced
Rhea RHEA:71815CC BY 4.0Reference data
Transported by SLCO2B1 or SLC16A2 or SLCO1A2 or SLC7A5 or SLCO4C1 or SLC16A10 or SLCO4A1 or SLCO1B3 or SLCO1C1 or SLCO3A1 or SLC17A4 or SLCO1B1
Reaction pageReversibleBalanced
Rhea RHEA:71819CC BY 4.0Reference data
3,3'-diiodo-L-thyronine3,3'-diiodo-L-thyronine
Transported by SLC43A1 or SLC16A2 or SLC7A5 or SLC43A2 or SLC7A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:71823CC BY 4.0Reference data
3,5-diiodo-L-tyrosine3,5-diiodo-L-tyrosine
Transported by SLC16A2 or SLC7A5 or SLC7A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:82879CC BY 4.0Reference data
3-iodo-L-tyrosine3-iodo-L-tyrosine
Transported by SLC43A1 or SLC16A2 or SLC7A5 or SLC43A2 or SLC7A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:82883CC BY 4.0Reference data