Proteins/UNIPROT:Q86UT5

NHERF4

ProteinUNIPROT:Q86UT5

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions..

Function from UniProtKB (Q86UT5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 2 reference databases · Subject: NHERF4 · Sources: Hetionet, Reactome

Order

ABCC2 interacts with NHERF4ProteinHetionet hetionet:interacts:1244-79849Inferred only
CFTR interacts with NHERF4ProteinHetionet hetionet:interacts:1080-79849Inferred only
GUCY2C interacts with NHERF4ProteinHetionet hetionet:interacts:2984-79849Inferred only
SLC15A1 interacts with NHERF4ProteinHetionet hetionet:interacts:6564-79849Inferred only
SLC15A2 interacts with NHERF4ProteinHetionet hetionet:interacts:6565-79849Inferred only
SLC22A3 interacts with NHERF4ProteinHetionet hetionet:interacts:6581-79849Inferred only
SLC22A4 interacts with NHERF4ProteinHetionet hetionet:interacts:6583-79849Inferred only
SLC22A5 interacts with NHERF4ProteinHetionet hetionet:interacts:6584-79849Inferred only
NHERF4 interacts with SLC22A9ProteinHetionet hetionet:interacts:114571-79849Inferred only
SLCO1C1 interacts with NHERF4ProteinHetionet hetionet:interacts:53919-79849Inferred only
SLCO3A1 interacts with NHERF4ProteinHetionet hetionet:interacts:28232-79849Inferred only
NHERF4 participates in Bacterial Infection PathwaysPathwayReactome R-HSA-9824439Inferred only

Show the remaining 4

NHERF4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
NHERF4 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
NHERF4 participates in Intestinal infectious diseasesPathwayReactome R-HSA-8942233Inferred only
NHERF4 participates in Uptake and actions of bacterial toxinsPathwayReactome R-HSA-5339562Inferred only

Other names

12 names

Resolves to: NHERF4

Also called: +IKEPPIntestinal and kidney-enriched PDZ proteinNa/Pi cotransporter C-terminal-associated protein 2NaPi-Cap2Natrium-phosphate cotransporter IIa C-terminal-associated protein 2NHERF-4PDZ domain-containing protein 2PDZ domain-containing protein 3PDZD3PDZK2Sodium-hydrogen exchanger regulatory factor 4

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