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Proteins/UNIPROT:Q96RN1
Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR. May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (By similarity). May play a role in sperm tail differentiation and motility and hence male fertility (By similarity)..
Function from UniProtKB (Q96RN1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 4 reference databases · Subject: SLC26A8 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Rhea
5 reactions
hydrogencarbonate+sulfatehydrogencarbonate+sulfate
Transported by SLC26A8 or SLC26A1 or SLC26A2 or SLC26A9 or SLC26A11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01914CC BY 4.0Reference data
3 names
Resolves to: SLC26A8
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR04946CC BY 4.0Reference data
chlorine(.)+2hydrogencarbonatechlorine(.)+2hydrogencarbonate
Transported by SLC26A8 or SLC26A7 or SLC26A2 or SLC26A9
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06534CC BY 4.0Reference data
oxalate+chlorideoxalate+chloride
Transported by SLC26A11 or SLC26A8 or SLC26A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:72263CC BY 4.0Reference data
sulfate+chloridesulfate+chloride
Transported by SLC26A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:75295CC BY 4.0Reference data