Proteins/UNIPROT:Q8NFU0

BEST4

ProteinUNIPROT:Q8NFU0Bestrophin-4

Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by Calcium (Ca2+). Mediates the movement of hydrogencarbonate and chloride..

Function from UniProtKB (Q8NFU0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 4 reference databases · Subject: BEST4 · Sources: Bgee, Hetionet, Reactome, Rhea

Order

ACOT4 covaries with BEST4ProteinHetionet hetionet:covaries:122970-266675Inferred only
ERAP2 covaries with BEST4ProteinHetionet hetionet:covaries:266675-64167Inferred only
IL17C covaries with BEST4ProteinHetionet hetionet:covaries:266675-27189Inferred only
NT5DC1 covaries with BEST4ProteinHetionet hetionet:covaries:221294-266675Inferred only
PROCA1 covaries with BEST4ProteinHetionet hetionet:covaries:147011-266675Inferred only
TMPRSS6 covaries with BEST4ProteinHetionet hetionet:covaries:164656-266675Inferred only
TNFSF18 covaries with BEST4ProteinHetionet hetionet:covaries:266675-8995Inferred only
ZFYVE9 covaries with BEST4ProteinHetionet hetionet:covaries:266675-9372Inferred only
ZNF26 covaries with BEST4ProteinHetionet hetionet:covaries:266675-7574Inferred only
BEST4 is expressed in mucosa of transverse colonAnatomyBgee ENSG00000142959Inferred only
BEST4 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
BEST4 participates in Stimuli-sensing channelsPathwayReactome R-HSA-2672351Inferred only

Show the remaining 3

BEST4 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
chloride is transported by BEST4CompoundRhea RHEA:29823Inferred only
hydrogencarbonate is transported by BEST4CompoundRhea RHEA:28695Inferred only

Reactions

2 reactions

hydrogencarbonatehydrogencarbonate
Transported by BEST1 or CFTR or CLDN17 or BEST4 or BEST2 or SLC26A7
Reaction pageRight to leftBalanced
Rhea RHEA:28695CC BY 4.0Reference data
chloridechloride
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or

Other names

3 names

Resolves to: BEST4

Also called: Bestrophin-4Vitelliform macular dystrophy 2-like protein 2VMD2L2

← Every protein Find it in the graph →