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Proteins/UNIPROT:Q8N9I9
Functions as an ubiquitin ligase protein, and regulates Notch signaling. By promoting the ubiquitination and subsequent degradation of target proteins, it can block activation of the Notch signaling pathway, potentially acting as a tumor suppressor in human cancers..
[Isoform 3]: Involved in the angiogenic EPHB4 kinase degradation in cancer cell..
Function from UniProtKB (Q8N9I9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
197 statements
197 statements · 3 reference databases · Subject: DTX3 · Sources: gene ontology, Hetionet, WikiPathways
6 names
Resolves to: DTX3