Proteins/UNIPROT:P39900

MMP12

ProteinUNIPROT:P39900

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

Function from UniProtKB (P39900), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 5 reference databases · Subject: MMP12 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Order

APP interacts with MMP12ProteinHetionet hetionet:interacts:351-4321Inferred only
ELN interacts with MMP12ProteinHetionet hetionet:interacts:2006-4321Inferred only
F12 interacts with MMP12ProteinHetionet hetionet:interacts:2161-4321Inferred only
LPA interacts with MMP12ProteinHetionet hetionet:interacts:4018-4321Inferred only
MMP12 interacts with PLAURProteinHetionet hetionet:interacts:4321-5329Inferred only
MMP12 interacts with TFPIProteinHetionet hetionet:interacts:4321-7035Inferred only
MMP12 participates in Chronic hyperglycemia impairment of neuron functionPathwayWikiPathways WP5283Inferred only
MMP12 participates in Collagen degradationPathwayReactome R-HSA-1442490Inferred only
MMP12 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
MMP12 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
MMP12 participates in Matrix metalloproteinasesPathwayWikiPathways WP129Inferred only
MMP12 participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only

Show the remaining 10

MMP12 regulates negative regulation of endothelial cell-matrix adhesionBiological processgene ontology P39900|GO:1904905Inferred only
MMP12 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P39900|GO:0000122Inferred only
MMP12 regulates negative regulation of type I interferon-mediated signaling pathwayBiological processgene ontology P39900|GO:0060339Inferred only
MMP12 regulates positive regulation of epithelial cell proliferation involved in wound healingBiological processgene ontology P39900|GO:0060054Inferred only
MMP12 regulates positive regulation of interferon-alpha productionBiological processgene ontology P39900|GO:0032727Inferred only
MMP12 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P39900|GO:0045944Inferred only
MMP12 regulates positive regulation of type I interferon-mediated signaling pathwayBiological processgene ontology P39900|GO:0060340Inferred only
MMP12 regulates regulation of defense response to virus by hostBiological processgene ontology P39900|GO:0050691Inferred only
MMP12 requires the cofactor Ca(2+)CompoundUniProt P39900Inferred only
MMP12 requires the cofactor Zn(2+)CompoundUniProt P39900Inferred only

Other names

6 names

Resolves to: MMP12

Also called: HMEMacrophage elastaseMatrix metalloproteinase-12MEMMEMMP-12

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