Proteins/UNIPROT:O43768

ENSA

ProteinUNIPROT:O43768

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents..

Function from UniProtKB (O43768), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

25 statements

25 statements · 3 reference databases · Subject: ENSA · Sources: gene ontology, Hetionet, Reactome

Order

GAL3ST2 covaries with ENSAProteinHetionet hetionet:covaries:2029-64090Inferred only
OPN1LW covaries with ENSAProteinHetionet hetionet:covaries:2029-5956Inferred only
PALM covaries with ENSAProteinHetionet hetionet:covaries:2029-5064Inferred only
TIMM13 covaries with ENSAProteinHetionet hetionet:covaries:2029-26517Inferred only
XKR6 covaries with ENSAProteinHetionet hetionet:covaries:2029-286046Inferred only
ENSA interacts with ABCC8ProteinHetionet hetionet:interacts:2029-6833Inferred only
ENSA interacts with ACDProteinHetionet hetionet:interacts:2029-65057Inferred only
ENSA interacts with ARIH2ProteinHetionet hetionet:interacts:10425-2029Inferred only
ENO2 interacts with ENSAProteinHetionet hetionet:interacts:2026-2029Inferred only
ENSA interacts with KCTD15ProteinHetionet hetionet:interacts:2029-79047Inferred only
ENSA interacts with MCM3ProteinHetionet hetionet:interacts:2029-4172Inferred only
ENSA interacts with PSEN1ProteinHetionet hetionet:interacts:2029-5663Inferred only

Show the remaining 13

ENSA interacts with RAP2AProteinHetionet hetionet:interacts:2029-5911Inferred only
ENSA interacts with SNCAProteinHetionet hetionet:interacts:2029-6622Inferred only
ENSA interacts with UBCProteinHetionet hetionet:interacts:2029-7316Inferred only
ENSA participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
ENSA participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
ENSA participates in M PhasePathwayReactome R-HSA-68886Inferred only
ENSA participates in MASTL Facilitates Mitotic ProgressionPathwayReactome R-HSA-2465910Inferred only
ENSA participates in Mitotic ProphasePathwayReactome R-HSA-68875Inferred only
ENSA regulates regulation of insulin secretionBiological processgene ontology O43768|GO:0050796Inferred only
PLAUR increases the expression of ENSAProteinHetionet hetionet:regulates:5329-2029Inferred only
SOD2 increases the expression of ENSAProteinHetionet hetionet:regulates:6648-2029Inferred only
STAT6 increases the expression of ENSAProteinHetionet hetionet:regulates:6778-2029Inferred only
SWAP70 increases the expression of ENSAProteinHetionet hetionet:regulates:23075-2029Inferred only

Other names

2 names

Resolves to: ENSA

Also called: Alpha-endosulfineARPP-19e

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