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Proteins/UNIPROT:Q8NHY0
Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa. Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells..
Function from UniProtKB (Q8NHY0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 5 reference databases · Subject: B4GALNT2 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea
8 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
4 names
Resolves to: B4GALNT2
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694c+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 10 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00924CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694g+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or POMGNT1 or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 16 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00925CC BY 4.0Reference data
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00926CC BY 4.0Reference data
an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative+UDP-N-acetyl-alpha-D-galactosamineCHEBI:232045+UDP+hydron
Catalysed by B4GALNT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81947CC BY 4.0Reference data
a 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-seryl-[protein]+UDP-N-acetyl-alpha-D-galactosaminea 3-O-{[alpha-Neu5Ac-(2->3)]-beta-D-GalNAc-(1->4)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-seryl-[protein]+UDP+hydron
Catalysed by B4GALNT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81955CC BY 4.0Reference data
a 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+UDP-N-acetyl-alpha-D-galactosaminea 3-O-{[alpha-Neu5Ac-(2->3)]-beta-D-GalNAc-(1->4)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+UDP+hydron
Catalysed by B4GALNT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81971CC BY 4.0Reference data
a neolactoside IV(3)-alpha-NeuAc-nLc4Cer+UDP-N-acetyl-alpha-D-galactosamineCHEBI:145079+UDP+hydron
Catalysed by B4GALNT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:82011CC BY 4.0Reference data