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Proteins/UNIPROT:Q96D59
Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. Mediates the ubiquitination and subsequent lysosomal degradation of ATP1B1 (By similarity)..
Function from UniProtKB (Q96D59), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 statements
9 statements · 2 reference databases · Subject: RNF183 · Sources: gene ontology, Hetionet
1 name
Resolves to: RNF183