Interaction of NuRD complexes with transcription factors

Numerous histone and DNA-binding domains in CHD, MTA, MBD and RBBP proteins contribute to the recruitment of the NuRD complex to DNA, where it appears to interact simultaneously with two adjacent nucleosomes (reviewed in Asamamaw et al, 2024; Reid et al, 2023). Recruitment to specific target genes is additionally mediated by protein-protein interactions between NuRD complex components and sequence-specific transcription factors, some of which are represented in this pathway (reviewed in Reid et al, 2023).

Summary from Reactome (R-HSA-9940951), read 2026-09-23.