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Proteins/UNIPROT:Q9Y3T9

NOC2L

Protein·UNIPROT:Q9Y3T9

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Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter..

Function from UniProtKB (Q9Y3T9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

46 statements

46 statements · 4 reference databases · Subject: NOC2L · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CACNA1B covaries with NOC2LProteinHetionet hetionet:covaries:26155-774Inferred only
DDX21 covaries with NOC2LProteinHetionet hetionet:covaries:26155-9188Inferred only
APP interacts with NOC2LProteinHetionet hetionet:interacts:26155-351Inferred only
ATN1 interacts with NOC2LProteinHetionet hetionet:interacts:1822-26155Inferred only
ATXN7 interacts with NOC2LProteinHetionet hetionet:interacts:26155-6314Inferred only
H2AC18; H2AC19 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8337Inferred only
NOC2L interacts with H2AC18; H2AC19ProteinHetionet hetionet:interacts:26155-723790Inferred only
H3-4 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8290Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8370Inferred only
NOC2L interacts with H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16ProteinHetionet hetionet:interacts:26155-554313Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8367Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8363Inferred only

Show the remaining 34

H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8368Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8359Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8364Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8362Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8294Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8360Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8365Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8366Inferred only
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 interacts with NOC2LProteinHetionet hetionet:interacts:26155-8361Inferred only
NOC2L interacts with H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16ProteinHetionet hetionet:interacts:121504-26155Inferred only
NOC2L interacts with LRIF1ProteinHetionet hetionet:interacts:26155-55791Inferred only
PPP1CA interacts with NOC2LProteinHetionet hetionet:interacts:26155-5499Inferred only
NOC2L interacts with RBFOX1ProteinHetionet hetionet:interacts:26155-54715Inferred only
NOC2L interacts with SIRT7ProteinHetionet hetionet:interacts:26155-51547Inferred only
SUMO2 interacts with NOC2LProteinHetionet hetionet:interacts:26155-6613Inferred only
TP53 interacts with NOC2LProteinHetionet hetionet:interacts:26155-7157Inferred only
UBC interacts with NOC2LProteinHetionet hetionet:interacts:26155-7316Inferred only
NOC2L participates in 1p36 copy number variation syndromePathwayWikiPathways WP5345Inferred only
NOC2L participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
NOC2L participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
NOC2L participates in Regulation of TP53 ActivityPathwayReactome R-HSA-5633007Inferred only
NOC2L participates in Regulation of TP53 Activity through PhosphorylationPathwayReactome R-HSA-6804756Inferred only
NOC2L participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
NOC2L participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
NOC2L regulates negative regulation of B cell apoptotic processBiological processgene ontology Q9Y3T9|GO:0002903Inferred only
NOC2L regulates negative regulation of intrinsic apoptotic signaling pathwayBiological processgene ontology Q9Y3T9|GO:2001243Inferred only
NOC2L regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9Y3T9|GO:0000122Inferred only
ASL decreases the expression of NOC2LProteinHetionet hetionet:regulates:435-26155Inferred only
FBP1 decreases the expression of NOC2LProteinHetionet hetionet:regulates:2203-26155Inferred only
FOSL2 decreases the expression of NOC2LProteinHetionet hetionet:regulates:2355-26155Inferred only
HDAC2 decreases the expression of NOC2LProteinHetionet hetionet:regulates:3066-26155Inferred only
KMT2A increases the expression of NOC2LProteinHetionet hetionet:regulates:4297-26155Inferred only
STAT5A decreases the expression of NOC2LProteinHetionet hetionet:regulates:6776-26155Inferred only
TRIM38 decreases the expression of NOC2LProteinHetionet hetionet:regulates:10475-26155Inferred only

Other names

5 names

Resolves to: NOC2L

Also called: NIRNOC2 homologNOC2-like proteinNovel INHAT repressorProtein NOC2 homolog

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