CHD3, CHD4, CHD5 subfamily

Subfamily II contains the best characterized CHD proteins, CHD3, CHD4 and CHD5. Although these enzymes are capable of hydrolyzing ATP in monomeric form to facilitate chromatin rearrangements, they are best characterized as part of larger macromolecular complexes such as NuRD and ChAPH (Low et al, 2016; Zhong et al, 2020; reviewed in Alendar and Berns, 2021; Reid et al, 2023; Reid et al, 2024)

Summary from Reactome (R-HSA-9943965), read 2026-09-23.