Proteins/UNIPROT:Q9NXW9

ALKBH4

ProteinUNIPROT:Q9NXW9Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity)..

Function from UniProtKB (Q9NXW9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: ALKBH4 · Sources: gene ontology, Hetionet, UniProt

Order

ALKBH4 covaries with C15orf61ProteinHetionet hetionet:covaries:145853-54784Inferred only
CPT1C covaries with ALKBH4ProteinHetionet hetionet:covaries:126129-54784Inferred only
ALKBH4 covaries with DENND2BProteinHetionet hetionet:covaries:54784-6764Inferred only
ALKBH4 covaries with FILIP1LProteinHetionet hetionet:covaries:11259-54784Inferred only
ALKBH4 covaries with HSPA1AProteinHetionet hetionet:covaries:3304-54784Inferred only
ALKBH4 covaries with MAPKBP1ProteinHetionet hetionet:covaries:23005-54784Inferred only
ALKBH4 interacts with DTX2ProteinHetionet hetionet:interacts:113878-54784Inferred only
ALKBH4 regulates positive regulation of gene expression, epigeneticBiological processgene ontology Q9NXW9|GO:0141137Inferred only
ALKBH4 requires the cofactor iron(2+)CompoundUniProt Q9NXW9Inferred only

Reactions

2 reactions

an N(6)-methyl-2'-deoxyadenosine in DNA+2-oxoglutarate(2-)+dioxygena 2'-deoxyadenosine in DNA+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by ALKBH1 or ALKBH4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:49524CC BY 4.0Reference data
N(6)-methyl-L-lysyl-[protein]+2-oxoglutarate(2-)+dioxygenL-lysyl-[protein]+

Other names

4 names

Resolves to: ALKBH4

Also called: ABH4Alkylated DNA repair protein alkB homolog 4DNA N6-methyl adenine demethylase ALKBH4Lysine-specific demethylase ALKBH4

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