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Proteins/UNIPROT:Q9Y4W2
Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2)..
Function from UniProtKB (Q9Y4W2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
68 statements
68 statements · 2 reference databases · Subject: LAS1L · Sources: Hetionet, Reactome
3 names
Resolves to: LAS1L