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Proteins/UNIPROT:P18510

IL1RN

Protein·UNIPROT:P18510

Open in the graph

Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens..

Function from UniProtKB (P18510), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

sterile multifocal osteomyelitis with periostitis and pustulosis has a germline basis in IL1RNDiseaseGenCC HGNC:6000|MONDO:0013021Inferred only

Statements

18 statements

18 statements · 4 reference databases · Subject: IL1RN · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ADH1B covaries with IL1RNProteinHetionet hetionet:covaries:125-3557Inferred only
IL1R1 interacts with IL1RNProteinHetionet hetionet:interacts:3554-3557Inferred only
IL1RN interacts with IL1R2ProteinHetionet hetionet:interacts:3557-7850Inferred only
IL1RN interacts with TERF2IPProteinHetionet hetionet:interacts:3557-54386Inferred only
IL1RN participates in 2q13 copy number variation syndromePathwayWikiPathways WP5222Inferred only
IL1RN participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
IL1RN participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL1RN participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL1RN participates in Interleukin-1 family signalingPathwayReactome R-HSA-446652Inferred only
IL1RN participates in Interleukin-1 signalingPathwayReactome R-HSA-9020702Inferred only
IL1RN participates in Interleukin-10 signalingPathwayReactome R-HSA-6783783Inferred only
IL1RN participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only

Show the remaining 6

IL1RN participates in Signal transduction through IL1RPathwayWikiPathways WP4496Inferred only
IL1RN participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL1RN participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
IL1RN regulates negative regulation of heterotypic cell-cell adhesionBiological processgene ontology P18510|GO:0034115Inferred only
IL1RN regulates negative regulation of inflammatory responseBiological processgene ontology P18510|GO:0050728Inferred only
IL1RN regulates negative regulation of interleukin-1-mediated signaling pathwayBiological processgene ontology P18510|GO:2000660Inferred only

Other names

8 names

Resolves to: IL1RN

Also called: AnakinraICIL-1RAIL-1raIL-1RNIL1 inhibitorIL1F3IL1RAIRAP

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